Table 2.
Patient survival according to clinical and laboratory characteristics.
| Deceased |
Alive |
Crude HR (95%CI) | p-value | |
|---|---|---|---|---|
| (n = 38) | (n = 62) | |||
| IHD, n (%) | 28 (73.7) | 26 (41.9) | 2.93 (1.41–6.07) | 0.004 |
| Age (years), median (IQR) | 66.0 (59.8–72.0) | 60.0 (50.0–66.0) | 1.21 (1.14–1.29) | <0.001 |
| Male, n (%) | 22 (57.9) | 45 (72.6) | 0.49 (0.26–0.94) | 0.032 |
| Smoking, n (%) | 10 (26.3) | 21 (33.9) | 1.05 (0.51–2.17) | 0.893 |
| Body mass index (kg/m2), median (IQR) | 26.0 (23.8–28.3) | 27.5 (23.8–31.5) | 0.94 (0.87–1.02) | 0.127 |
| Renal failure, n (%) | 9 (23.7) | 11 (17.7) | 1.10 (0.52–2.32) | 0.807 |
| Hypertension, n (%) | 16 (42.1) | 24 (38.7) | 1.08 (0.57–2.07) | 0.808 |
| Diabetes mellitus, n (%) | 14 (36.8) | 18 (29.0) | 1.39 (0.72–2.69) | 0.329 |
| LVEF, median (IQR) | 56.0 (48.0–60.0) | 60.0 (55.0–60.0) | 0.94 (0.89–0.97) | 0.001 |
| Cholic acid, median (IQR) | 7.5 (4.8–22.3) | 21.0 (6.5–46.5) | 0.99 (0.98–1.01) | 0.305 |
| Cholic acid >14 mg/24 h, n (%) | 13 (34.2) | 35 (56.5) | 0.54 (0.28–1.06) | 0.075 |
| Chenodeoxycholic acid, median (IQR) | 7.5 (0.0–22.0) | 8 (8.0–15.5) | 0.99 (0.97–1.02) | 0.586 |
| Chenodeoxycholic >8 mg/24 h, n (%) | 16 (42.1) | 28 (45.2) | 1.09 (0.58–2.08) | 0.764 |
| Deoxychcholic acid, median (IQR) | 154.5 (109.8–212.5) | 290.5 (185.5–482.5) | 0.993 (0.99–0.997) | <0.001 |
| Deoxychcholic acid >214 mg/24 h, n (%) | 9 (23.7) | 40 (64.5) | 0.27 (0.13–0.57) | 0.001 |
| Lithocholic acid, median (IQR) | 83.0 (59.6–131.3) | 184.0 (132.8–243.0) | 0.987 (0.982–0.992) | <0.001 |
| Lithocholic >141 mg/24 h, n (%) | 6 (15.8) | 44 (71.0) | 0.16 (0.07–0.38) | <0.001 |
| Total bile acid, median (IQR) | 277.0 (193.2–349.5) | 601.5 (415.0–734.5) | 0.994 (0.992–0.997) | <0.001 |
| Total bile acid >415 mg/24 h, n (%) | 4 (10.5) | 46 (74.2) | 0.09 (0.03–0.27) | <0.001 |
| Triglycerides, median (IQR) | 207.0 (173–264.8) | 214.5 (1496.0–264.5) | 1.001 (0.997–1.004) | 0.750 |
| Triglycerides >250 mg/dL, n (%) | 11 (28.9) | 18 (29.0) | 1.13 (0.56–2.29) | 0.727 |
| LDL, median (IQR) | 151.5 (125.5–183.5) | 132.5 (116.3–175.0) | 1.006 (1.000–1.013) | 0.068 |
| LDL >130 mg/, mg/dL n (%) | 28 (73.7) | 37 (59.7) | 1.64 (0.79–3.38) | 0.178 |
| HDL, median (IQR) | 42.0 (36.8–51.3) | 48.5 (38.0–59.0) | 0.98 (0.95–1.01) | 0.089 |
| HDL <45 mg/dL, n (%) | 22 (57.9) | 25 (40.3) | 1.45 (0.76–2.76) | 0.262 |
| Total cholesterol, median (IQR) | 246.0 (216.25–288.0) | 236.5 (215.0–276) | 1.005 (0.999–1.011) | 0.103 |
| Total cholesterol >200 mg/dL, n (%) | 32 (84.2) | 52 (83.9) | 0.99 (0.41–2.38) | 0.987 |
HDL, high-density lipoprotein; IHD, ischemic heart disease; IQR, interquartile range; LDL, low-density lipoprotein; LVEF, left ventricular ejection fraction.