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. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Efficacy of afatinib (blue), copanlisib (red) and a combination of afatinib and copanlisib (green) in a panel of cell lines which are (a) wild type (WT) for both PIK3CA and ERBB family genes, (b) PIK3CA Mut/ERBB family WT, (c) ERBB family Mut/PIK3CA WT and (d) ERBB family/PIK3CA Mut. Error bars are representative of standard deviations across triplicate experiments. The ratio of afatinib to copanlisib in this assay is fixed at either 16:1 or 4:1 depending on the cell line. ED, effective dose; Mut, mutation; WT, wild type.