Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — The impact of (a) copanlisib, (b) afatinib or (c) copanlisib and afatinib on expression and phosphorylation of proteins in the PI3K/AKT or MAPK/ERK signaling pathways relative to vehicle treated controls as measured by reverse phase protein array analysis. ‘•’ represents the ERBB/PIK3CA wild type (WT) cell line (KLE), ‘’ the PIK3CA mutation (Mut)/ERBB family WT cell line (HT29), ‘□’ the ERBB family Mut/PIK3CA WT cell line (C2BBE1) and ‘’ the ERBB family/PIK3CA Mut cell line (H1975). Error bars are representative of standard deviations across triplicate independent experiments. Fold changes of ⩾1.2 and with a p value of <0.05 as calculated by Student’s t test are classified as significant by the use of an asterisk of a similar color to the relevant cell line.

Inline graphic — The impact of (a) copanlisib, (b) afatinib or (c) copanlisib and afatinib on expression and phosphorylation of proteins in the PI3K/AKT or MAPK/ERK signaling pathways relative to vehicle treated controls as measured by reverse phase protein array analysis. ‘•’ represents the ERBB/PIK3CA wild type (WT) cell line (KLE), ‘’ the PIK3CA mutation (Mut)/ERBB family WT cell line (HT29), ‘□’ the ERBB family Mut/PIK3CA WT cell line (C2BBE1) and ‘’ the ERBB family/PIK3CA Mut cell line (H1975). Error bars are representative of standard deviations across triplicate independent experiments. Fold changes of ⩾1.2 and with a p value of <0.05 as calculated by Student’s t test are classified as significant by the use of an asterisk of a similar color to the relevant cell line.