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. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — The impact of vehicle, copanlisib, afatinib or a combination of copanlisib (Cop, C) and afatinib (Afat, A) on apoptosis induction in (a) the ERBB/PIK3CA wild type (WT) cell line (KLE), (b) the PIK3CA mutation (Mut)/ERBB family WT cell line (HT29), (c) the ERBB family Mut/PIK3CA WT cell line (C2BBE1) and (d) the ERBB family/PIK3CA Mut cell line (H1975) as determined using fluorescence-activated cell sorting (FACS) analysis of propidium iodide/annexin V stained cells. Red bars represent apoptotic cells and green bars represent necrotic cells. Error bars are representative of standard deviations across triplicate independent experiments.