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. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — The impact of the combination of copanlisib and afatinib on expression and phosphorylation of proteins in the apoptotic signaling pathway relative to vehicle-treated controls as measured by reverse phase protein array analysis. ‘•’ represents the ERBB/PIK3CA wild type (WT) cell line (KLE), ‘’ the PIK3CA mutation (Mut)/ERBB family WT cell line (HT29), ‘□’ the ERBB-family Mut/PIK3CA WT cell line (C2BBE1) and ‘’ the ERBB family/PIK3CA Mut cell line (H1975). Error bars are representative of standard deviations across triplicate independent experiments. Changes of ⩾±20% and with a p value of <0.05 as calculated by Student’s t test are classified as significant.

Inline graphic — The impact of the combination of copanlisib and afatinib on expression and phosphorylation of proteins in the apoptotic signaling pathway relative to vehicle-treated controls as measured by reverse phase protein array analysis. ‘•’ represents the ERBB/PIK3CA wild type (WT) cell line (KLE), ‘’ the PIK3CA mutation (Mut)/ERBB family WT cell line (HT29), ‘□’ the ERBB-family Mut/PIK3CA WT cell line (C2BBE1) and ‘’ the ERBB family/PIK3CA Mut cell line (H1975). Error bars are representative of standard deviations across triplicate independent experiments. Changes of ⩾±20% and with a p value of <0.05 as calculated by Student’s t test are classified as significant.