Table 5.

Comparison of sensitivity to PI3K inhibitors copanlisib (C)⁸⁴, pictilisib (P)⁸⁵ and gedatolisib (G)⁸⁶ in a panel of cell lines with multiple histologies, based on their ERBB family or PIK3CA mutational status.

	ERBB family PIK3CA WT			ERBB family WT/PIK3CA Mut			ERBB family Mut/PIK3CA WT			ERBB family/PIK3CA Mut
	C	P	G	C	P	G	C	P	G	C	P	G
No. cell lines	31	9	7	8	4	5	11	6	2	11	4	3
Min IC50	7	1150	20	5	141	1	2	173	14	7	116	8
Max IC50	5000	2190	433	215	1780	50	144	998	24	153	1080	36
Mean IC50	429.5	1774	121.7	66.5	827.5	19.4	51.36	613.8	19	51	626	19.33
Std. dev	994.1	373.6	163.4	82	689.7	22.59	41.34	301.7	7.071	53.05	395	14.74
Std. error	178.5	124.5	61.75	28.99	344.8	10.1	12.47	123.2	5	15.99	197.5	8.511
p value versus WT	n/a	n/a	n/a	0.046	0.025	n/s	0.039	0.002	n/s	0.024	0.007	n/s

Mut, mutation; WT, wild type; IC50, half-maximal inhibitory concentration.