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. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040

Table 6.

Comparison of sensitivity to PI3K inhibitors copanlisib (C)84, pictilisib (P)85 and gedatolisib (G)86 in a panel of cell lines with multiple histologies, based on their ERBB family mutational status.

ERBB family PIK3CA WT
All ERBB family Mut
C P G C P G
No. cell lines 31 9 7 22 10 5
Minimum 7 1150 20 2 116 8
Maximum 5000 2190 433 153 1080 36
Mean 429.5 1774 121.7 51.18 618.7 19.2
Std. deviation 994.1 373.6 163.4 46.41 320.3 11.01
Std. error 178.5 124.5 61.75 9.895 101.3 4.923
p value versus all ERBB Mut n/a n/a n/a 0.005 3*10−4 0.048

Mut, mutation; WT, wild type.