Table 7.
Mutational status of the panel of cell lines used for the in vitro assays in this manuscript representing the ERBB family and PIK3CA mutational status of the cell lines. We also included potential confounding mutations such as RAS, RAF and PTEN mutations, which may confound the effects of ERBB family or PIK3CA mutations.
| Cell line | Histology | Group | EGFR mutation | ERBB2 mutation | ERBB3 mutation | ERBB4 mutation | PIK3CA mutation | KRAS mutation | PTEN mutation | BRAF mutation | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SW620 | Colorectal | 1/RAS | WT | WT | WT | WT | WT | G12V | N/A | N/A | APC (Q1338*) |
| CL-14 | Colorectal | 1 | WT | WT | WT | WT | WT | N/A | N/A | N/A | p53 (R273C), APC (S1032*, S1044L, S1068*) |
| KLE | Endometrial | 1 | WT | WT | WT | WT | WT | N/A | N/A | N/A | p53 (R175H) |
| T47D | Breast | 2 | WT | WT | WT | WT | H1047R | N/A | N/A | N/A | p53 (L194F) |
| HT29 | Colorectal | 2 | WT | WT | WT | WT | P449T | N/A | N/A | V600, T119S | APC (E853*, .E1554fs) |
| MFE-280 | Endometrial | 2 | WT | WT | WT | WT | H1047Y | N/A | N/A | N/A | p53 (A307_splice) |
| C2BBe1 | Colorectal | 3 | WT | WT | D857N | WT | WT | N/A | N/A | N/A | MTOR (Y1151C), p53(E204*), APC (Q1367* |
| LoVo | Colorectal | 3/RAS | WT | WT | WT | R782Q | WT | G13D | N/A | N/A | RAF-1 (G370del, V98A), APC (R1114*, T1430fs, R2816Q |
| CaOV-3 | Ovarian | 3 | R255Q | WT | WT | WT | WT | N/A | N/A | N/A | p53 (Q136*) |
| MCF-7 | Breast | 4 | WT | WT | WT | Y1242C | E545K | N/A | N/A | N/A | N/A |
| HCT116 | Colorectal | 4/RAS | WT | WT | Q261* | WT | H1047R | G13D | N/A | N/A | BRCA2 (I2672fs) |
N/A, not applicable; WT, wild type; *, nonsense mutation.