Figure 2.

Plasma concentration of vonoprazan after a single oral dose of 20 mg.

Pharmacokinetics after an oral dose of 20 mg vonoprazan given either before or after breakfast were similar. Elimination half-life (t_1/2) of vonoprazan was also similar irrespective of the timing of prescription. The t_1/2 was about 7.7 h in this experiment, which is much longer than conventional proton-pump inhibitors (see Table 2). This data was adopted from Pharmaceuticals and Medical Devices Agency of Japan.³²