Figure 3.
Response for pH > 4 holding time with various doses of vonoprazan.
Vonoprazan dose dependently prolonged 24 h pH > 4 holding time in healthy young male volunteers. The proportion of time (%) of gastric pH > 4 in 24 h (a) and night time (20:00 to 08:00) (b) after a single morning dose for 7 days was depicted using data from Jenkins and colleagues.34 As noted, differences between volunteers from the UK and Japan were small in both profiles. Notably, a single morning dose of vonoprazan effectively increased night time pH > 4 holding time, if the higher dose was used.