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. 2018 Jan 9;11:1756283X17745776. doi: 10.1177/1756283X17745776

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© The Author(s), 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Metabolic disposition pathways of vonoprazan.

The major route of metabolic disposition of vonoprazan was reported via CYP3A4, which converts vonoprazan to compounds M-I and M-III (thick arrows). Although CYP2D6, CYP2C9 and CYP2C19, and sulfotransferase2A1 (SULT2A1) also participate in metabolic disposition, their roles are relatively minor. M-I-G^* and M-II-G^* were inferred glucuronic-acid-conjugated (G) products from M-I, and M-II, respectively. Data are taken from the Pharmaceuticals and Medical Devices Agency of Japan³² with some modifications.