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. 2018 Jan 22;13:479–492. doi: 10.2147/IJN.S154968

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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TEM images of RWM in the control group and intratympanic injection of PLGA NPs group. Subcellular characteristics of RWM in the control group (A, B) and intratympanic injection of PLGA NPs for 30-minute group (C–F). (A) Tight junctions which sealed the paracellular space between adjacent cells and a variety of organelles were found in the RWM outer epithelium layer. (B) There were four layers in the RWM inner epithelium layer, and each layer was marked by a rectangular frame; the large extracellular spaces were marked by double arrows. (C) Successive transport behavior, including endocytic pit, intracellular vesicles, and exocytic pit, was captured. Extensive endocytic and exocytic behaviors (D–F) and closed tight junction (D) in the RWM outer epithelium layer. Exocytotic release behavior was also observed in the RWM inner epithelium layer (F).

Abbreviations: TEM, transmission electron microscope; RWM, round window membrane; PLGA NPs, poly (lactic-co-glycolic acid) nanoparticles; M, mitochondria; N, nucleus; TJ, tight junction; G, Golgi apparatus; BM, basement membrane; CF, collagenous fiber.