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. 2018 Jan 22;13:479–492. doi: 10.2147/IJN.S154968

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Colocalization analysis of PLGA NPs with lysosomes. CLSM micrographs of outer epithelium cells of RWM after intratympanic injection of PLGA NPs for 30 minutes (A). Colocalization scatterplots of PLGA NPs with lysosomes (B). Colocalization mask images showing only overlapping pixels (C). Quantitative colocalization parameters of PLGA NPs with lysosomes by measuring Manders’ overlap coefficient and Pearson’s correlation coefficient (D).

Abbreviations: PLGA NPs, poly (lactic-co-glycolic acid) nanoparticles; CLSM, confocal laser scanning microscope; RWM, round window membrane; DAPI, 4′,6-diamidino-2-phenylindole.