Table 5.
Pathways statistically significantly enriched by PPRV infection in EECs
| Pathway ID | Definition | Fisher-P value | Enrichment_score | Genes |
|---|---|---|---|---|
| Pathway of upregulated genes in PPRV 1 hpi | ||||
| chx05140 | Leishmaniasis—Capra hircus (goat) | 4.22314E−06 | 5.374365 | IL1A//NFKBIA//TGFB3//TNF |
| chx04668 | TNF signaling pathway—Capra hircus (goat) | 1.77336E−05 | 4.751203 | CXCL1//JUNB//NFKBIA//TNF |
| chx04380 | Osteoclast differentiation—Capra hircus (goat) | 3.09217E−05 | 4.509736 | IL1A//JUNB//NFKBIA//TNF |
| chx05160 | Hepatitis C—Capra hircus (goat) | 4.21687E−05 | 4.37501 | CLDN7//IRF1//NFKBIA//TNF |
| chx05321 | Inflammatory bowel disease (IBD)—Capra hircus (goat) | 0.000139054 | 3.856817 | IL1A//TGFB3//TNF |
| chx05134 | Legionellosis—Capra hircus (goat) | 0.000195553 | 3.708736 | CXCL1//NFKBIA//TNF |
| chx05133 | Pertussis—Capra hircus (goat) | 0.000203515 | 3.691403 | IL1A//IRF1//TNF |
| chx04210 | Apoptosis—Capra hircus (goat) | 0.000337929 | 3.471175 | IL1A//NFKBIA//TNF |
| chx05323 | Rheumatoid arthritis—Capra hircus (goat) | 0.000409628 | 3.387611 | IL1A//TGFB3//TNF |
| chx05166 | HTLV-I infection—Capra hircus (goat) | 0.000632975 | 3.198613 | NFKBIA//TGFB3//TNF//ZFP36 |
| Pathway of downregulated genes in PPRV 1 hpi | ||||
| There is no enriched pathway | ||||
| Pathway of upregulated genes in PPRV 24 hpi | ||||
| chx05140 | Leishmaniasis—Capra hircus (goat) | 0.000419393 | 3.377379 | C3//IL10//NCF1//TLR4 |
| chx05322 | Systemic lupus erythematosus—Capra hircus (goat) | 0.002795802 | 2.553494 | C3//CD28//IL10//TROVE2 |
| chx05205 | Proteoglycans in cancer—Capra hircus (goat) | 0.002919602 | 2.534676 | ARHGEF1//ESR1//IGF2//MMP2//TLR4 |
| chx05320 | Autoimmune thyroid disease—Capra hircus (goat) | 0.002956794 | 2.529179 | CD28//IL10//TSHB |
| chx04110 | Cell cycle—Capra hircus (goat) | 0.003229311 | 2.49089 | BUB1//CCNA2//CCNB1//PCNA |
| chx05133 | Pertussis—Capra hircus (goat) | 0.005551826 | 2.255564 | C3//IL10//TLR4 |
| chx04914 | Progesterone-mediated oocyte maturation—Capra hircus (goat) | 0.008113843 | 2.090773 | BUB1//CCNA2//CCNB1 |
| chx04145 | Phagosome—Capra hircus (goat) | 0.008982425 | 2.046606 | C3//COLEC12//NCF1//TLR4 |
| chx05310 | Asthma—Capra hircus (goat) | 0.009715281 | 2.012545 | IL10//MS4A2 |
| chx05323 | Rheumatoid arthritis—Capra hircus (goat) | 0.01065279 | 1.972537 | ANGPT1//CD28//TLR4 |
| Pathway of downregulated genes in PPRV 24 hpi | ||||
| chx05205 | Proteoglycans in cancer—Capra hircus (goat) | 1.05326E−06 | 5.977465 | IQGAP1//MAP2K1//MYC//PLAU//PLAUR// RAC1//SDC4//TNF//VEGFA |
| chx04380 | Osteoclast differentiation—Capra hircus (goat) | 3.21792E−06 | 5.492424 | FOS//IL1A//JUNB//MAP2K1//NFKBIA// RAC1//TNF |
| chx04668 | TNF signaling pathway—Capra hircus (goat) | 1.89215E−05 | 4.723044 | FOS//JUNB//MAP2K1//NFKBIA//SELE//TNF |
| chx05020 | Prion diseases—Capra hircus (goat) | 2.63214E−05 | 4.57969 | EGR1//HSPA5//IL1A//MAP2K1 |
| chx04662 | B cell receptor signaling pathway—Capra hircus (goat) | 3.0485E−05 | 4.515913 | FOS//MAP2K1//NFKBIA//NFKBIB//RAC1 |
| chx05140 | Leishmaniasis—Capra hircus (goat) | 4.28445E−05 | 4.368105 | FOS//IL1A//NFKBIA//NFKBIB//TNF |
| chx05323 | Rheumatoid arthritis—Capra hircus (goat) | 0.000141883 | 3.848068 | ATP6V1B2//FOS//IL1A//TNF//VEGFA |
| chx04621 | NOD-like receptor signaling pathway—Capra hircus (goat) | 0.000161774 | 3.791092 | HSP90AA1//NFKBIA//NFKBIB//TNF |
| chx04660 | T cell receptor signaling pathway—Capra hircus (goat) | 0.000207727 | 3.682506 | FOS//MAP2K1//NFKBIA//NFKBIB//TNF |
| chx04620 | Toll-like receptor signaling pathway—Capra hircus (goat) | 0.000217362 | 3.662817 | FOS//MAP2K1//NFKBIA//RAC1//TNF |