Table 2.
Genes significantly associated with ritodrine-induced side effects
| Gene symbol | Gene name | FDR | P | G (mean ± SD) | Gene functional category | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case, (n = 13) | Control, (n = 30) | ION | ATP | Ca2+ | CP | PK | ||||
| AASDH | Aminoadipate-Semialdehyde Dehydrogenase | 0.019104 | 0.000041 | 0.16 ± 0.19 | 0.58 ± 0.44 | ✓ | ✓ | |||
| ARMC9 | Armadillo Repeat Containing 9 | 0.025396 | 0.000057 | 0.06 ± 0.03 | 0.44 ± 0.46 | ✓ | ||||
| B9D2 | B9 Protein Domain 2 | 0.012597 | 0.000017 | 0.25 ± 0.33 | 0.82 ± 0.36 | ✓ | ||||
| BLK | B lymphoid tyrosine kinase | 0.007009 | 0.000004 | 0.16 ± 0.00 | 0.58 ± 0.43 | ✓ | ||||
| CARS2 | Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative) | 0.068711 | 0.000227 | 0.23 ± 0.35 | 0.73 ± 0.43 | ✓ | ✓ | |||
| CD1A | CD1a Molecule | 0.061968 | 0.000192 | 0.35 ± 0.37 | 0.86 ± 0.33 | |||||
| CSPG5 | Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C) | 0.075577 | 0.000336 | 0.24 ± 0.00 | 0.49 ± 0.36 | |||||
| CYP1A1 | Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 | 0.065067 | 0.000209 | 0.03 ± 0.03 | 0.36 ± 0.46 | ✓ | ✓ | ✓ | ||
| CYP8B1 | Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 | 0.012973 | 0.000020 | 0.45 ± 0.09 | 0.71 ± 0.26 | ✓ | ✓ | |||
| FAT4 | FAT Atypical Cadherin 4 | 0.092483 | 0.000539 | 0.23 ± 0.10 | 0.43 ± 0.28 | ✓ | ✓ | |||
| FUT6 | Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) | 0.051144 | 0.000147 | 0.14 ± 0.04 | 0.46 ± 0.42 | |||||
| GALNT10 | Polypeptide N-Acetylgalactosaminyltransferase 10 | 0.092483 | 0.000549 | 0.35 ± 0.21 | 0.66 ± 0.35 | ✓ | ||||
| HHATL | Hedgehog Acyltransferase-Like | 0.076828 | 0.000369 | 0.27 ± 0.11 | 0.50 ± 0.30 | |||||
| IFT74 | Intraflagellar Transport 74 | 0.011408 | 0.000014 | 0.25 ± 0.10 | 0.56 ± 0.32 | ✓ | ||||
| ICE1 | Interactor Of Little Elongation Complex ELL Subunit 1 | 0.014088 | 0.000026 | 0.49 ± 0.08 | 0.70 ± 0.23 | |||||
| KNDC1 | Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 | 0.099453 | 0.000617 | 0.34 ± 0.03 | 0.53 ± 0.29 | |||||
| NKAIN3 | Na+/K+ Transporting ATPase Interacting 3 | 0.014088 | 0.000026 | 0.21 ± 0.08 | 0.56 ± 0.40 | ✓ | ||||
| OR6B1 | Olfactory Receptor, Family 6, Subfamily B, Member 1 | 0.092483 | 0.000562 | 0.28 ± 0.02 | 0.50 ± 0.33 | |||||
| PSMD9 | Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 | 0.092483 | 0.000511 | 0.43 ± 0.40 | 0.91 ± 0.25 | |||||
| PXT1 | Peroxisomal, Testis Specific 1 | 0.075577 | 0.000336 | 0.02 ± 0.00 | 0.35 ± 0.47 | |||||
| RBBP8NL | RBBP8 N-Terminal Like | 0.092483 | 0.000564 | 0.21 ± 0.25 | 0.58 ± 0.43 | |||||
| RSPH3 | Radial Spoke 3 Homolog (Chlamydomonas) | 0.012770 | 0.000018 | 0.27 ± 0.07 | 0.61 ± 0.37 | ✓ | ||||
| SERPINA7 | Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 | 0.077599 | 0.000400 | 0.31 ± 0.48 | 0.90 ± 0.30 | ✓ | ||||
| SLC12A7 | Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 7 | 0.051144 | 0.000148 | 0.36 ± 0.04 | 0.60 ± 0.31 | ✓ | ||||
| SPTA1 | Spectrin, Alpha, Erythrocytic 1 | 0.008266 | 0.000007 | 0.32 ± 0.08 | 0.49 ± 0.15 | ✓ | ✓ | |||
| TNKS | Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase | 0.077599 | 0.000401 | 0.38 ± 0.19 | 0.68 ± 0.33 | ✓ | ||||
| ZDHHC12 | Zinc Finger, DHHC-Type Containing 12 | 0.075577 | 0.000332 | 0.17 ± 0.15 | 0.41 ± 0.27 | ✓ | ||||
| ZNF273 | Zinc Finger Protein 273 | 0.092483 | 0.000527 | 0.10 ± 0.05 | 0.38 ± 0.42 | ✓ | ||||
FDR false discovery rate, G gene deleteriousness score, ION ion binding, ATP adenosine triphosphate binding, Ca2+ calcium-related, CP ciliopathy, PK pharmacokinetics–relate