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. 2017 Mar 21;50(1):148–155. doi: 10.4143/crt.2016.511

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Copyright © 2018 by the Korean Cancer Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — The topotecan-vincristine-doxorubicin (TVD) salvage therapy for children included in the HR-NBL-1 protocol. Patients with persistent metastatic disease after the COJEC induction therapy of the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol were eligible for TVD therapy with the aim of eradicating the metastatic disease. Children achieving complete remission (CR) or good partial response (GPR) become eligible for consolidation with high dose therapy (HDT) as planned by the original HR-NBL-1 protocol, all the other were considered failures. PPR, poor partial response; MR, mixed response; SD, stable disease; PD, progressive disease.