Table 4.
Grade 3-4 toxicity after 126 TVD courses in 63 patients
| Toxicity | 1st course | 2nd course | Overall | Patients |
|---|---|---|---|---|
| Hematologic | ||||
| Neutropenia | 55 (87.3) | 51 (80.9) | 106 (84.1) | 57 (90.5) |
| Thrombocytopenia | 54 (85.7) | 50 (79.4) | 104 (82.5) | 58 (92.1) |
| Anaemia | 40 (63.5) | 37 (58.7) | 77 (61.1) | 48 (76.2) |
| Nonhematologic | ||||
| Fever > 38°C | 29 (46.0) | 24 (38.1) | 53 (42.1) | 38 (60.3) |
| Mucositis | 17 (27.0) | 8 (12.7) | 25 (19.8) | 20 (31.7) |
| Vomiting | 2 (3.2) | 1 (1.3) | 3 (2.4) | 3 (4.8) |
| Constipation | 1 (1.6) | 0 (0.0) | 1 (0.8) | 1 (1.6) |
| Sensory neuropathy | 2 (3.2) | 1 (1.6) | 3 (2.4) | 2 (3.2) |
Values are presented as number (%). TVD, topotecan-vincristine-doxorubicin.