Table 1.

Characteristics of Patients with secondary pulmonary alveolar proteinosis in Peking Union Medical College Hospital

	Gender	Age	Smoking	Clinical Symptoms	Diagnostic Procedure	Primary Disease	PaO2 mmHg
1	Male	38	Current	Weight loss, weakness, night sweats	BALF	MDS-MLD	64.1
2	Female	26	Never	Fever, productive cough	CT guided percutaneous lung biopsy	TB	94.5
3	Male	20	Current	Exertional dyspnea, dry cough	Surgical biopsy	CML	97.4
4	Male	26	Never	Weakness, fever	BALF+TBLB	MDS-SLD	NA
5	Male	37	Never	Dyspnea, dry cough	BALF	MDS-U	48
6	Male	33	Never	Fever, weight loss, weakness	Surgical biopsy	MDS-EB	34.6
7	Male	56	Never	Fever, dry cough	VATS	TB	84.1
8	Female	54	Never	Weight loss,weakness, fever	CT guided percutaneous lung biopsy	TB	39
9	Female	51	Never	Dyspnea, productive cough	BALF	TB	35.6
	CT Scan Features				Comorbidity/Complication	Treatment	Outcomes
1	diffused bilateral GGO				None	WLL, Danazol, Retinoic acid,	Die
2	bilateral GGO patchy geographic pattern, interlobular septal thickening,small scattered nodules				Hepatitis	INH, RIF, EMB, Levofloxacin	Recovery
3	bilateral GGO patchy geographic pattern, bilateral cysts				None	Hydroxyurea	NA
4	diffused bilateral GGO, small nodules				Type B viral hepatitis	Prednisone	Die
5	bilateral GGO with a crazy paving pattern,enlarged mediastinal lymph nodes				Mycobacterium cheloneiinfection	Antibiotics, traditional medicine	Die
6	diffused bilateral GGO, interlobular septal thickening,small scattered nodules				Hospital acquired pneumonia	Danazol, Retinoic acid, WLL	Die
7	bilateral GGO with a crazy paving pattern, interlobular septal thickening				None	INH, RIF, EMB,Clarithromycin, Oxifloxacin	Improved
8	diffused bilateral GGO, small scattered nodules				None	INH, RIF, EMB,Rifapentine	Stable
9	diffused bilateral GGO, septal thickening				Thrombopenia, Sjogren’s syndrome	INH, RIF, EMB,Levofloxacin, WLL	Improved

BALF broncho-alverolar lavage fluid, CML chronic myelogenousleukemia;EMB ethambutol, GGO ground-glass opacities, INH isonicotinic acid hydrazide, MDS myelodysplastic syndrome(SLD:single lineage dysplasia; MLD: multilineage dysplasia; EB: excess blasts; U: unclassifiable), NA not available, RIF rifampicine, TB tuberculosis, TBLB transbronchial lung biopsy, VATS via video-assisted thoracic surgery, WLL whole lung lavage