Table 5.
Diagnostic value of cerebrospinal fluid biomarkers in differential diagnosis of prion disease
| Prion disease vs. other NDs | Atypical prion disease vs. other a/rpNDs | |||||||||
| AUC | Cutoff | Sensitivity (%) | Specificity (%) | AUC | Cutoff | Sensitivity (%) | Specificity (%) | |||
| NfL | 0.926 ± 0.016 | > | 5016 pg/ml | 89.2 | 83.4 | 0.839 ± 0.040 | > | 4500 pg/ml | 85.5 | 75 |
| t-tau | 0.939 ± 0.014 | > | 1100 pg/ml | 89.2 | 84.1 | 0.722 ± 0.048 | > | 1100 pg/ml | 74.5 | 57.1 |
| t-tau/p-tau | 0.982 ± 0.009 | > | 14.0 | 96.2 | 95.4 | 0.930 ± 0.028 | > | 14.0 | 89.1 | 89.3 |
| NfL/p-tau | 0.904 ± 0.019 | > | 113.0 | 87.7 | 83.4 | 0.866 ± 0.039 | > | 95.0 | 89.1 | 82.1 |
| Prion disease vs. AD | Atypical prion disease vs. a/rpAD | |||||||||
| AUC | Cutoff | Sensitivity (%) | Specificity (%) | AUC | Cutoff | Sensitivity (%) | Specificity (%) | |||
| NfL | 0.981 ± 0.007 | > | 4363 pg/ml | 94.3 | 94.5 | 0.946 ± 0.021 | > | 4363 pg/ml | 86.4 | 91.9 |
| t-tau | 0.901 ± 0.021 | > | 1100 pg/ml | 89.1 | 69.9 | 0.654 ± 0.057 | > | 1100 pg/ml | 75.9 | 48.6 |
| t-tau/p-tau | 0.986 ± 0.008 | > | 14.0 | 94.7 | 95.9 | 0.958 ± 0.022 | > | 14.0 | 89.3 | 94.6 |
| NfL/p-tau | 0.994 ± 0.004 | > | 60.0 | 96.2 | 95.9 | 0.989 ± 0.007 | > | 60.0 | 92.9 | 97.3 |
Abbreviations: AD Alzheimer’s disease, a/rp Atypical/rapidly progressive, ND Neurodegenerative dementia, NfL Neurofilament light chain protein, p-tau Phosphorylated tau protein, t-tau Total tau protein, > greater than