Table 1.

Population parameters and interanimal variabilities estimates for experiment one data

Parameters	Description	Units	Estimates	RSEa (%)	IAVb %
$\alpha$	Proliferation rate	Day−1	$0.767$	8	$8.62$
$\beta$	Exponential decay rate of the relative tumor growth rate (Gompertz model)	Day−1	$0.037$	$10$	$57.3$
$\gamma$	Baseline effect of the chemotherapy	(mg/g)−1.day−1	$1$	$-$	$-$
$\delta$	Cytotoxics efficacy improvement following vascular normalization	(mg/mL)−1	$\mathrm{1,200}$	$36$	$0$
$\tau$	Delay parameter for dynamics of $Q$	Day	$2$	$20$	$10$
$k$	Delay of the tumor cell loss following chemotherapy	Day−1	$0.3$	$-$	$-$
Σ	Exponential error parameter	$-$	$0.951$	$4$	$-$

IAV, interanimal variabilities; RSE, relative standard error.

Values of the parameters corresponding to the adapted fit. See Supplementary Methods for details on the estimation procedure.

^aRSE is a measure of the precision of the parameter estimates, expressed as coefficient of variation (CV%).

^bThe IAV is the standard deviation ω estimated using Monolix software.