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. 2018 Jan 15;35(2):393–397. doi: 10.1089/neu.2017.5258

FIG. 1.

FIG. 1.

Cortical inhibition measurements by ppTMS. Given that log transform of conditioning/test MEP values were used to avoid floor effect, lower values correspond to greater inhibition (A). Decrease in cortical inhibition 90 min post-TBI. Ninety minutes after sham or verum injury at baseline, the median cortical inhibition was 24% and 14% in sham (n = 13) and TBI (n = 18) groups, respectively (p = 0.038). (B) Enhanced cortical inhibition after HupA. Cortical inhibition changes were observed for 90 min after HupA (0.6 mg/kg) or vehicle injection. Injections were 90 min after the surgery and immediately after the baseline ppTMS session. HupA enhanced cortical inhibition after both sham injury (++p = 0.002) and TBI (*p = 0.017). HupA, huperzine A; ppTMS, paired-pulse transcranial magnetic stimulation; TBI, traumatic brain injury.