Table 2.

Summary of Cytokine Induction

	Cytokine induced
Cytokine added	Pattern 1 (concentration dependent)	Pattern 2 (time dependent)	Pattern 3 (time and concentration dependent)
IL-1β	IP10
IL-6	IL-1α, IL-4, sCD40L	IL-1ra, IL-5, IL-13, MIP1α, RANTES	EGF, FGF-2, Fractalkine, GM-CSF, IFNα2, IFNγ, IL-7, IL-12p40, IL-12p70, MIP1β, sIL-2Ra, TNFβ
TNF	Eotaxin, GM-CSF, IP10	Fractalkine, IL-6, IL-10, PDGF ABBB	GRO, IL-1α, IL-7, IL-8, MCP3, MIP1β, RANTES, sCD40L

IP-10, interferon gamma-induced protein 10; sCD40L, soluble CD40 ligand; MIP1α, macrophage inflammatory protein 1 alpha; RANTES, regulated on activation, normal T cell expressed and secreted; EGF, epidermal growth factor; FGF2, fibroblast growth factor 2; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; MIP1β, macrophage inflammatory protein 1 beta; sIL-2Ra, soluble interleukin-2 receptor antagonist; PDGF, platelet-derived growth factor; MCP-3, monocyte chemotactic protein-3.

The three patterns of cytokine induction detected after interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) exposure. Pattern 1: concentration dependent but time independent cytokine response; Pattern 2: time dependent but concentration independent cytokine response; Pattern 3: time and concentration dependent cytokine response.