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. 2018 Jan 15;35(2):375–392. doi: 10.1089/neu.2017.5256

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© Uylissa A. Rodriguez et al., 2017; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 7. — Effects of blast-induced traumatic brain injury (bTBI) on mean arterial blood pressure (MAP), relative cerebral perfusion, and cerebral vascular resistance (CVR) after penicillamine methyl ester (PenME) treatment (n = 8/group). (A) MAP was significantly elevated in the bTBI group compared with the sham and bTBI+PenME groups. However, there were no statistically significant differences between the sham and bTBI+PenME groups (p = 0.24, sham vs. bTBI+PenME). (B) Relative cerebral perfusion was significantly reduced in both the bTBI and bTBI+PenME groups compared with sham but did not differ significantly between the bTBI and bTBI+PenME groups (p = 0.11, bTBI vs. bTBI+PenME). (C) CVR was significantly elevated in the bTBI group compared with the sham and bTBI+PenME groups, but was significantly reduced in the bTBI+PenME group compared with both the sham and bTBI groups. Values are means ± SEM. *p < 0.01 versus sham; **p < 0.001 versus bTBI+PenME; ***p < 0.0001 versus sham; ^††p < 0.0001 versus bTBI+PenMe; ^†††p < 0.0001 versus bTBI.