Table 4.

Effects of ABS bTBI on MAP, Relative Cerebral Perfusion and CVR after PenME Administration

	p value
MAP (bTBI vs. sham)	<0.01
MAP (bTBI vs. bTBI+PenME)	0.001
MAP (sham vs. bTBI+PenME)	0.24
Relative cerebral perfusion (bTBI vs. sham)	<0.0001
Relative cerebral perfusion (bTBI vs. bTBI+PenME)	0.11
Relative cerebral perfusion (sham vs. bTBI+PenME)	<0.0001
CVR (bTBI vs. sham)	<0.01
CVR (bTBI vs. bTBI+PenME)	<0.0001
CVR (sham vs. bTBI+PenME)	<0.0001

ABS, Advanced Blast Simulator; bTBI, blast-induced traumatic brain injury; MAP, mean arterial blood pressure; CVR, cerebral vascular resistance; PenME, penicillamine methyl ester