Table 3. Results from the unconditional analysis and analysis conditional on offspring (row 2 of each SNP) or maternal genotype (row 4 of each SNP) for the most significant SNPs from each locus that reached P<10⁻⁵ from the discovery meta-analysis.

	Genome	Chr	Position (bp)	EA/OA	Early GWG				Late GWG				Total GWGa
					N	Betaa	s.e.	P-value	N	Betaa	s.e.	P-value	N	Beta	s.e.	P-value
rs481396 (TMEM163)
Unconditional	Mat	2	134 953 875	T/C	6635	0.040	0.019	0.03	6674	0.057	0.019	2.3 × 10−3	12 844	0.036	0.013	7.0 × 10−3
Conditional	Mat	2	134 953 875	T/C	6103	0.041	0.022	0.06	6165	0.050	0.022	0.03	10 079	0.031	0.017	0.07
Unconditional	Off	2	134 953 875	T/C	6291	0.040	0.019	0.04	6356	0.031	0.019	0.11	11 340	0.033	0.015	0.03
Conditional	Off	2	134 953 875	T/C	6103	0.012	0.022	0.59	6165	0.011	0.023	0.64	10 079	0.019	0.018	0.28
rs3924699 (LCORL)
Unconditional	Mat	4	18 300 153	G/C	6630	0.068	0.030	0.02	6670	0.075	0.030	0.01	12 830	0.055	0.021	7.6 × 10−3
Conditional	Mat	4	18 300 153	G/C	6091	0.052	0.035	0.14	6155	0.050	0.035	0.15	10 031	0.030	0.027	0.28
Unconditional	Off	4	18 300 153	G/C	6283	0.050	0.030	0.09	6350	0.074	0.030	0.01	11 241	0.047	0.023	0.05
Conditional	Off	4	18 300 153	G/C	6091	0.025	0.035	0.47	6155	0.045	0.035	0.20	10 031	0.027	0.028	0.33
rs9995522 (UGDH)
Unconditional	Mat	4	39 179 591	A/G	6638	0.113	0.035	1.5 × 10−3	6677	−0.020	0.026	0.44	12 838	0.055	0.026	0.03
Conditional	Mat	4	39 179 591	A/G	6101	0.041	0.042	0.34	6163	0.039	0.043	0.36	10 057	0.037	0.033	0.26
Unconditional	Off	4	39 179 591	A/G	6288	0.179	0.035	4.8 × 10−7	6354	−0.007	0.036	0.84	11 289	0.070	0.026	6.4 × 10−3
Conditional	Off	4	39 179 591	A/G	6101	0.163	0.041	8.2 × 10−5	6163	−0.024	0.042	0.56	10 057	0.060	0.031	0.05
rs6457375 (HLA-C)
Unconditional	Mat	6	31 380 591	G/A	5474	0.057	0.019	3.1 × 10−3	5446	0.009	0.020	0.64	9530	0.020	0.014	0.16
Conditional	Mat	6	31 380 591	G/A	5378	0.052	0.022	0.02	5366	0.014	0.022	0.52	8688	0.029	0.017	0.09
Unconditional	Off	6	31 380 591	G/A	5480	0.023	0.020	0.23	5458	0.020	0.007	0.74	9388	0.005	0.015	0.71
Conditional	Off	6	31 380 591	G/A	5378	−0.0005	0.022	0.98	5366	−0.002	0.023	0.93	8688	−0.011	0.017	0.53
rs13295979 (ERCC6L2/HSD17B3)
Unconditional	Mat	9	97 879 618	T/G	5826	0.117	0.040	3.7 × 10−3	5805	0.118	0.041	3.9 × 10−3	11 087	0.061	0.027	0.03
Conditional	Mat	9	97 879 618	T/G	5577	0.086	0.046	0.06	5564	0.105	0.047	0.02	9367	0.055	0.034	0.10
Unconditional	Off	9	97 879 618	T/G	5668	0.095	0.041	0.02	5643	0.103	0.042	0.01	10 051	0.094	0.030	2.1 × 10−3
Conditional	Off	9	97 879 618	T/G	5577	0.051	0.046	0.26	5564	0.052	0.046	0.27	9367	0.061	0.035	0.08
rs1702200 (GLRX3/TCERG1L)
Unconditional	Mat	10	132 346 882	G/T	6636	0.008	0.017	0.65	6675	0.044	0.017	0.01	12 840	0.027	0.012	0.03
Conditional	Mat	10	132 346 882	G/T	6105	0.003	0.021	0.90	6167	0.054	0.021	0.01	10 082	0.032	0.016	0.05
Unconditional	Off	10	132 346 882	G/T	6290	−0.011	0.018	0.54	6356	0.022	0.018	0.23	11 328	0.021	0.014	0.13
Conditional	Off	10	132 346 882	G/T	6105	0.001	0.021	0.97	6167	−0.019	0.021	0.37	10 082	−0.001	0.016	0.97
rs7133083 (RBM19)
Unconditional	Mat	12	112 942 277	A/G	5834	0.099	0.025	5.3 × 10−5	5812	0.042	0.025	0.09	11 147	0.040	0.017	0.02
Conditional	Mat	12	112 942 277	A/G	5580	0.105	0.029	2.7 × 10−4	5566	0.036	0.029	0.21	9430	0.042	0.022	0.06
Unconditional	Off	12	112 942 277	A/G	5667	0.033	0.025	0.20	5642	0.026	0.025	0.31	10 089	0.038	0.019	0.05
Conditional	Off	12	112 942 277	A/G	5580	−0.011	0.029	0.70	5566	0.001	0.029	0.96	9430	0.022	0.022	0.32
rs7301563 (NTF3)
Unconditional	Mat	12	5 436 393	T/C	6636	0.041	0.022	0.07	6681	0.023	0.022	0.30	12 841	0.021	0.016	0.20
Conditional	Mat	12	5 436 393	T/C	6084	−0.012	0.026	0.64	6146	0.013	0.027	0.63	9965	0.002	0.021	0.94
Unconditional	Off	12	5 436 393	T/C	6274	0.105	0.022	3.2 × 10−6	6340	0.028	0.023	0.22	11 100	0.064	0.018	3.3 × 10−4
Conditional	Off	12	5 436 393	T/C	6084	0.089	0.026	7.5 × 10−4	6146	0.044	0.027	0.10	9965	0.071	0.021	8.7 × 10−4
rs310087 (SYT4)
Unconditional	Mat	18	39 147 836	A/G	6641	0.012	0.017	0.49	6680	0.020	0.017	0.24	12 848	0.016	0.012	0.18
Conditional	Mat	18	39 147 836	A/G	6104	−0.009	0.020	0.66	6166	−0.001	0.021	0.95	10 059	−0.014	0.016	0.39
Unconditional	Off	18	39 147 836	A/G	6288	0.035	0.017	0.04	6353	0.057	0.017	1.1 × 10−3	11 278	0.058	0.014	1.6 × 10−5
Conditional	Off	18	39 147 836	A/G	6104	0.041	0.020	0.04	6166	0.057	0.021	5.3 × 10−3	10 059	0.067	0.016	3.1 × 10−5
rs16989175 (PSG5)
Unconditional	Mat	19	48 337 381	G/C	6637	0.039	0.020	0.06	6676	0.003	0.020	0.87	16 162	0.029	0.013	0.02
Conditional	Mat	19	48 337 381	G/C	6085	0.026	0.034	0.28	6147	−0.024	0.024	0.32	13 143	0.004	0.017	0.82
Unconditional	Off	19	48 337 381	G/C	6273	0.057	0.021	7.4 × 10−3	6339	0.049	0.021	0.02	14 363	0.058	0.014	3.7 × 10−5
Conditional	Off	19	48 337 381	G/C	6085	0.042	0.024	0.08	6147	0.050	0.025	0.04	13 143	0.055	0.017	9.6 × 10−4

Abbreviations: EA/OA, effect allele/other allele; GWG, gestational weight gain; Mat, maternal genome; Off, Offspring (that is, fetal genome; SNP, single-nucleotide polymorphism.

The nearest gene is used as the locus name.

Results from the maternal and offspring genotypes are presented.

^aBeta values are the difference in mean GWG in kg per week of gestation per additional effect allele.