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. Author manuscript; available in PMC: 2018 Jun 21.
Published in final edited form as: N Engl J Med. 2017 Dec 21;377(25):2456–2464. doi: 10.1056/NEJMoa1707568

Figure 3. Brain Volume.

Figure 3

Panels A and B show brain-volume trajectories for female and male patients, determined by examination of preoperative, 6-month postoperative, and 12-month postoperative scans. Curve fits (Weibull distribution) to normative data26 are indicated with black lines representing the age-adjusted mean and 1 and 2 SD above and below the mean. The scans represented by the circled data points in Panel A are shown in Panels C and D (for a patient in each treatment group who had catch-up growth to the normal range), and the scans represented by circled data points in Panel B are shown in Panels E and F (for a patient in each treatment group who had growth failure). In Panels C through F, the preoperative (baseline) scan is shown on the left, and the corresponding 12-month postoperative scan is shown on the right.