Table 1.
Characteristics of the Patients at Baseline.*
| Characteristic | Overall (N = 100) | ETV–CPC Group (N = 51) | Ventriculoperitoneal-Shunt Group (N = 49) |
|---|---|---|---|
| Median age at randomization (IQR) — mo | 3.1 (2.6 to 4.1) | 3.1 (2.2 to 4.2) | 3.1 (2.7 to 3.9) |
| Female sex — no. (%) | 39 (39) | 21 (41) | 18 (37) |
| Median weight (IQR) — kg | 6.0 (5.0 to 7.0) | 5.6 (4.5 to 7.0) | 6.2 (5.4 to 7.2) |
| Median head circumference (IQR) — cm | 48.5 (45.2 to 50.8) | 48.1 (44.5 to 50.0) | 48.7 (45.8 to 53.5) |
| Median BSID-3 scaled score (IQR)† | |||
| Cognitive | 1 (1 to 5) | 1 (1 to 5) | 1 (1 to 5) |
| Expressive language | 3 (1 to 6) | 3 (1 to 7) | 2 (1 to 6) |
| Receptive language | 6 (1 to 8) | 6 (2 to 9) | 5 (1 to 8) |
| General motor | 3 (1 to 5) | 3 (1 to 6) | 2 (1 to 4) |
| Fine motor | 3 (1 to 5) | 4 (1 to 6) | 3 (1 to 4) |
| Median CSF volume (IQR) — cm3 | 783 (570 to 1050) | 741 (542 to 992) | 824 (639 to 1345) |
| Median z score for brain volume (IQR) | −2.6 (−3.2 to −1.9) | −2.6 (−3.1 to −2.1) | −2.4 (−3.4 to −1.8) |
| Normal brain volume — no./total no. (%) | 10/99 (10) | 5/50 (10) | 5/49 (10) |
*
Data on brain volume and cerebrospinal fluid (CSF) volume were available for 50 infants in the endoscopic third ventriculostomy with choroid plexus cauterization (ETV–CPC) group and 49 infants in the ventriculoperitoneal-shunt group. There were significant between-group differences in head circumference (P = 0.03 by Mann–Whitney test) and CSF volume (P = 0.05 by Mann–Whitney test). IQR denotes interquartile range.
†
Bayley Scales of Infant Development, Third Edition (BSID-3), scaled scores range from 1 to 19, with higher scores indicating better performance. The scores are scaled to a mean (±SD) of 10±3 in the general population.