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. Author manuscript; available in PMC: 2018 Jun 11.
Published in final edited form as: Nat Biotechnol. 2017 Dec 11;36(1):89–94. doi: 10.1038/nbt.4042

Figure 1. Demuxlet: demultiplexing and doublet identification from single cell data.

Figure 1

a) Pipeline for experimental multiplexing of unrelated individuals, loading onto droplet-based single-cell RNA-sequencing instrument, and computational demultiplexing (demux) and doublet removal using demuxlet. Assuming equal mixing of 8 individuals, b) 4 genetic variants can recover the sample identity of a cell, and c) 87.5% of doublets will contain cells from two different samples.