Table 2. Correlation between the total number of cerebral microbleeds and demographics, drugs, clinical and other neuroimaging features in 125 CADASIL patients.
| Number of CMB mean (SD) |
p* | p** | |
|---|---|---|---|
| Male gender (yes vs no) | 3.8 (9.9) vs 3.8 (10.9) | 0.981 | 0.676 |
| Ischemic stroke (yes vs no) | 5.5 (11.3) vs 2.7 (9.7) | 0.144 | 0.980 |
| TIA (yes vs no) | 7.8 (17.1) vs 3.0 (8.6) | 0.065 | 0.662 |
| Recurrent ischemic events (yes vs no) | 5.6 (9.8) vs 3.2 (10.6) | 0.286 | 0.501 |
| Hemorrhagic stroke (yes vs no) | 25.3 (21.8) vs 3.3 (9.5) | <0.001 | 0.001 |
| Cognitive impairment (yes vs no) | 8.8 (15.3) vs 0.8 (3.6) | <0.001 | 0.140 |
| Dementia (yes vs no) | 22.4 (24.2) vs 2.4 (6.9) | <0.001 | <0.001 |
| Psychiatric disturbances (yes vs no) | 4.0 (8.9) vs 3.6 (11.5) | 0.833 | 0.575 |
| Migraine (yes vs no) | 1.3 (4.4) vs 8.8 (16.0) | <0.001 | <0.001 |
| Migraine with aura (yes vs no) | 1.1 (4.7) vs 6.3 (13.3) | 0.005 | 0.004 |
| Prolonged aura (yes vs no) | 0.4 (1.0) vs 4.1 (10.9) | 0.169 | 0.141 |
| Seizures (yes vs no) | 9.6 (15.0) vs 3.2 (9.7) | 0.051 | 0.265 |
| Acute reversible encephalopathy (yes vs no) | 1.2 (2.8) vs 4.1 (11.0) | 0.306 | 0.246 |
| Urge incontinence (yes vs no) | 12.0 (17.8) vs 1.4 (5.2) | <0.001 | 0.008 |
| Hypertension (yes vs no) | 8.0 (15.7) vs 2.0 (6.4) | 0.003 | 0.650 |
| Diabetes (yes vs no) | 7.3 (15.8) vs 3.6 (10.0) | 0.363 | 0.870 |
| Hypercholesterolemia (yes vs no) | 5.0 (10.0) vs 2.5 (11.2) | 0.199 | 0.721 |
| History of smoking (yes vs no) | 3.4 (9.1) vs 4.2 (11.6) | 0.680 | 0.821 |
| Hyperhomocysteinemia (yes vs no) | 6.4 (15.8) vs 3.4 (8.9) | 0.236 | 0.386 |
| Antithrombotic treatment (yes vs no) | 5.0 (12.0) vs 1.6 (6.1) | 0.111 | 0.450 |
| Statins use (yes vs no) | 3.8 (7.5) vs 3.9 (12.2) | 0.967 | 0.009 |
| Fazekas grade 1 (yes vs no) | 0.0 (0.0) vs 4.6 (11.3) | 0.036 | 0.429 |
| Fazekas grade 2 (yes vs no) | 0.2 (0.5) vs 4.4 (11.3) | ||
| Fazekas grade 3 (yes vs no) | 5.7 (12.4) vs 0.1 (0.3) | ||
| Pontine leukoaraiosis (yes vs no) | 5.9 (13.0) vs 0.9 (3.9) | 0.007 | 0.918 |
| Temporal pole involvement (yes vs no) | 4.0 (10.7) vs 2.5 (8.2) | 0.619 | 0.968 |
| External capsule involvement (yes vs no) | 4.9 (11.6) vs 0.0 (0.2) | 0.026 | 0.106 |
| Lacunar infarcts (yes vs no) | 5.8 (12.5) vs 0.2 (1.2) | 0.003 | 0.916 |
CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; CMB: cerebral microbleeds; SD: standard deviations; TIA: transient ischemic attack
* ANOVA
** ANOVA adjusted for age
p values reported in bold are statistically significant