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. 2018 Jan 25;13(1):e0191697. doi: 10.1371/journal.pone.0191697

Table 5. An admission BUN concentration above 28mg/dL is associated with mortality after correction for several cofounders in a multivariate analysis.

Hazard ratios (HR) were obtained by Cox regression analysis, for the multivariate regression models, a backward variable elimination was performed. Elimination criterion was a p-value of more than 0.10.

multivariate model 1
  univariate multivariate
  HR 95%CI p-value HR 95%CI p-value
BUN >28 mg/dL 3.74 3.29–4.25 <0.001 1.89 1.59–2.26 <0.001
APACHE2 1.07 1.07–1.08 <0.001 1.07 1.06–1.08 <0.001
multivariate model 2
  univariate multivariate
  HR 95%CI p-value HR 95%CI p-value
BUN >28 mg/dL 3.74 3.29–4.25 <0.001 1.85 1.55–2.21 <0.001
SAPS2 1.04 1.03–1.04 <0.001 1.03 1.03–1.04 <0.001
multivariate model 3
  univariate multivariate
  HR 95%CI p-value HR 95%CI p-value
BUN >28 mg/dl 3.74 3.29–4.25 <0.001 3.34 2.89–3.86 <0.001
creatinine (mg/dL) 1.001 1.001–1.001 <0.001 1.02 0.98–1.05 0.44
age (y) 1.02 1.02–1.03 <0.001 1.02 1.01–1.02 <0.001
sex (m/w) 0.97 0.86–1.08 0.55 0.9 0.79–1.03 0.9
lactate (mmol/L) 1.06 1.06–1.07 <0.001 1.07 1.06–1.07 <0.001