Fig. 4.

mAb 2A5 protects human liver chimeric mice from HCV challenge. Three days before viral infection, humanized mice were passively immunized with 1 mg of mAb 2A5. Mice were challenged with mH77 (gt1a, 10⁴ IU HCV RNA), mP05 (gt1b, 10⁴ IU), mED43 (gt4a, 10⁴ IU) or mHK6a (gt6a, 10⁵ IU). Viremia was quantified until week 8 post infection. 2A5-treated and control mice are represented by closed and open circles, respectively. Mice that scored HCV RNA negative are displayed below the dashed line representing the limit of quantification (LOQ; HCV RNA <750 IU/mL).