Table 2.

Disease-associated predictive factors for development of pouchitis

Pre-surgical	Surgical	Post-surgical
Pre-operative steroid use27, 42	Hand sewn anastomosis43	Positive fecal lactoferrin36
Primary sclerosing cholangitis40, 44	Anastomosis placed <0.5cm from pectinate line43	Non-steroidal anti-inflammatory drug (NSAID) use32, 45
Pulmonary comorbidity29	S-pouch construction29	Iron deficiency anemia46
Extraintestinal manifestations23, 26–32		Thrombocytosis27
Backwash ileitis40, 47		Longer duration of follow-up/time since pouch construction27, 38, 40
Pancolitis/extensive disease29, 30, 38, 39		Ulcerative gastroduodenal lesions48
UC Disease severity49		Non-daily proton pump inhibitor (PPI)/H2 antagonist use50
Steroid dependency49
First-degree relative with IBD31
Chronic active inflammation of the appendix39
Presence of a concomitant autoimmune disorder33