Figure 5.

Transport and anchoring. (a) Schematic representation of Egl-BicD mediated transport of K10 mRNA. Structural information is currently available for K10 TLS (PDB 2KE6³³); for the first and second coiled coil regions of BicD in complex with the Dynein:Dynactin molecular motor (PDB 5AFU⁸²); and for the C-terminal coiled coil region of BicD, with the Egl-binding site defined by mutation analysis (PDB 4BL6⁸³). Still unknown are the molecular details of Egl interaction with the RNA and with BicD, as well as the connection between BicD N-terminal and C-terminal coiled coil domains. (b) Crystal structure of a fragment of Mira coiled coil region bound to the fifth dsRBD (dsRBD5) of Stau (PDB 5CFF⁹¹). BicD and Mira both act as homodimers.