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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):344–355. doi: 10.1016/j.celrep.2017.06.040

Figure 4. Persistent ΔFosB expression leads to desensitization of c-Fos expression with repetitive seizures.

Figure 4

(A) Hippocampal c-Fos mRNA expression in NTG mice is increased 1–2 hrs after single administration of 15 mg/kg KA, but returns to baseline at 4.5 hrs (n = 3–4/group). (B) DG ΔFosB IR was increased in mice that received multiple administrations of 15 mg/kg KA. (C) The increase in c-Fos mRNA expression after each KA injection is attenuated with multiple injections, which is first evident when ΔFosB expression increases as shown in panel B. Data were normalized to saline-treated control values (rel to Sal). *p<0.05, **p<0.01, ***p<0.001. Error bars indicate SEM. See also Figure S4 and Tables S3–S4.