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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):344–355. doi: 10.1016/j.celrep.2017.06.040

Figure 5. Acute HDAC inhibition partially restores c-Fos induction in APP mice.

Figure 5

(A) NTG but not APP mice exhibit increased total c-Fos IR in the hippocampus after exploration of a novel environment for 2 hrs (NE +) relative to home cage controls (NE −) (n = 9–10/group). (B,C) Neither NTG nor APP mice exhibit significant increases in the total number of c-Fos IR cells when exposed to NE 1 hr after 4-PBA treatment (n = 6/group) or 2 hrs after MS-275 treatment (n = 8–10/group). (D) In control conditions, NTG but not APP mice exhibit increased numbers of c-Fos-IR cells above optical threshold when exposed to NE vs. home cage (n = 9–10/group). (E,F) Both NTG and APP mice exhibit increased number of c-Fos-IR cells above optical threshold when exposed to NE 1 hr after 4-PBA treatment (n = 6/group) or 2 hrs after MS-275 treatment (n = 8–10/group). (G,H) Histone H4 acetylation on the Fos promoter in APP mice is normalized after treatment with 4-PBA (n = 6/group) or MS-275 (n = 6/group). Data in panels D-F were normalized to NTG home cage control values (rel to NTG/–). *p<0.05, ***p<0.001. Error bars indicate SEM. See also Figure S5–S6, and Tables S3–S4.