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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):344–355. doi: 10.1016/j.celrep.2017.06.040

Figure 6. Acute HDAC inhibition improves hippocampus-dependent learning and memory in APP mice.

Figure 6

(A,B) APP mice exhibited increased time interacting with the displaced object during the test phase of the task when, prior to training, they were treated with either 4-PBA (n = 5–6/group) or MS-275 (n = 6/group) relative to treatment with vehicle (control). (C, D) Increased ΔFosB expression in APP vs. NTG mice is unaffected by 4-PBA (n = 5–6/group) or MS-275 (n = 7/group). Data in panels C–D were normalized to vehicle-treated NTG values (rel to NTG/Ctrl). *p<0.05, **p<0.01, ***p<0.001, ns, non-significant. Error bars indicate SEM. See also Tables S3–S4.