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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):344–355. doi: 10.1016/j.celrep.2017.06.040

Figure 7. Direct inhibition of ΔFosB signaling improves c-Fos expression and hippocampus-dependent memory in APP mice.

Figure 7

(A) Unilateral AAV-GFP/ΔJunD infusion into the right DG achieves robust ΔJunD overexpression in comparison with AAV-GFP infused into the contralateral side. (B) Bilateral AAV-ΔJunD infusion into the DG of APP mice improves performance in the object location memory task. (C) Bilateral AAV-GFP/ΔJunD (ΔJunD) infusion into the DG of NTG and APP mice achieves robust ΔJunD overexpression vs. AAV-GFP (GFP) control. (D) ΔJunD overexpression does not impact ΔFosB expression in APP mice. (E) ΔJunD overexpression restores c-Fos expression in APP mice. JunD/ΔJunD and ΔFosB quantification data were normalized to AAV-GFP-treated NTG values (rel to NTG/GFP). n = 5–8/group for panels B-E. *p<0.05, **p<0.01, ***p<0.001, ns, non-significant. Error bars indicate SEM. See also Figure S7 and Tables S3–S4.