Table 4.

Fibromyalgia – Effective Medications based on Included Studies

Fibromyalgia – Effective Medications
FDA On-Label	Off-Label
NSAIDs
None	None
Amine Reuptake Inhibitors (ARI)
Duloxetine, Milnacipran	Amitriptyline, Fluoxetine,Paroxetine (controlled-release)
Membrane Stabilizer
Pregabalin	Gabapentin
Muscle Relaxants
None	Cyclobenzaprine
ARI/Opioid
None	Tramadol/acetaminophen
Opioid Antagonists
None	Low-dose Naltrexone
NMDA Antagonists
None	Memantine
Local Anesthetics
None	None
Miscellaneous
None	Nabilone

FDA: Food and Drug Administration; NSAIDs: non-steroidal anti-inflammatory drugs; ARI: amine reuptake inhibitor; NMDA: N-methyl-D-aspartate