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. 2017 Dec 18;128(2):625–643. doi: 10.1172/JCI89212

Figure 9. HIF-1α–induced miR-200b suppression facilitates cancer metastasis.

Figure 9

(A–C) CT-26/Luc mouse colon cancer cells stably expressing WT or HLH-truncated HIF-1α were restored with miR-200b for metastasis animal experiments (A). After intrasplenic injection, tumor metastasis was monitored by in vivo images of mouse (A) liver and lung (B). (C) The photon intensities of the metastatic signals in the livers and lungs were calculated 18 days after intrasplenic injection (n = 7 per group). Data are presented as mean ± SD, with at least n = 3 per group. Multigroup comparisons were analyzed by 1-way ANOVA with Tukey’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001.