Table 1.
Polymorphism (reference genotype) | Comparison genotype | Triglycerides, mg/dLb
|
HDL-C, mg/dL
|
LDL-C, mg/dL
|
|||
---|---|---|---|---|---|---|---|
Mean (SE) | P c | Mean (SE) | P | Mean (SE) | P | ||
ABCA1 | |||||||
| |||||||
1051G/A (GG) | GA | 0.078 (0.034) | 0.02 | −0.93 (0.89) | 0.30 | 1.7 (2.2) | 0.44 |
| |||||||
AA | −0.026 (0.047) | 0.58 | 1.68 (1.24) | 0.18 | −5.8 (3.0) | 0.056 | |
| |||||||
CETP | |||||||
| |||||||
TaqIB (B1B1) | B1B2 | −0.025 (0.033) | 0.45 | 2.13 (0.86) | 0.014 | 3.0 (2.2) | 0.16 |
| |||||||
B2B2 | −0.095 (0.047) | 0.04 | 6.62 (1.22) | 6.7 × 10−8 | 0.1 (3.0) | 0.98 | |
| |||||||
−2505C/A (CC) | CA | −0.055 (0.032) | 0.90 | 2.92 (0.84) | 5.5 × 10−4 | 0.2 (2.1) | 0.91 |
| |||||||
AA | −0.111 (0.052) | 0.03 | 6.72 (1.34) | 6.6 × 10−7 | 4.7 (3.3) | 0.16 | |
| |||||||
−629C/A (CC) | CA | −0.026 (0.038) | 0.49 | 0.92 (0.98) | 0.35 | 1.5 (2.4) | 0.55 |
| |||||||
AA | −0.088 (0.043) | 0.04 | 5.18 (1.12) | 4.7 × 10−6 | 0.7 (2.8) | 0.81 | |
| |||||||
A373P (AA) | AP | 0.115 (0.051) | 0.03 | −3.03 (1.34) | 0.024 | 4.2 (3.3) | 0.21 |
| |||||||
PP | 0.530 (0.338) | 0.12 | −18.78 (8.87) | 0.035 | −1.0 (21.7) | 0.96 | |
| |||||||
R451Q (RR) | RQ | 0.114 (0.058) | 0.049 | −3.39 (1.52) | 0.026 | 5.7 (3.7) | 0.13 |
| |||||||
0.528 (0.338) | 0.12 | −18.75 (8.87) | 0.035 | −0.9 (21.7) | 0.97 |
Adjusted for age, sex, race/ethnicity, BMI, waist circumference, diabetes, serum insulin level, smoking, and use of lipid-lowering medications.
To convert triglyceride concentrations to mmol/L, multiply by 0.0113; to convert HDL-C and LDL-C concentrations to mmol/L, multiply by 0.0259. Triglyceride values are log-transformed.
P values are based on t-test comparing mean of comparison genotype to the indicated reference genotype for each polymorphism using a codominant model.