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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: Clin Chem. 2009 Jan 8;55(3):481–488. doi: 10.1373/clinchem.2008.107995

Table 1.

Differences in lipid concentrations between ABCA1 and CETP polymorphisms compared with reference genotype, in a subsample of the MESA population.a

Polymorphism (reference genotype) Comparison genotype Triglycerides, mg/dLb
HDL-C, mg/dL
LDL-C, mg/dL
Mean (SE) P c Mean (SE) P Mean (SE) P
ABCA1

 1051G/A (GG) GA 0.078 (0.034) 0.02 −0.93 (0.89) 0.30 1.7 (2.2) 0.44

AA −0.026 (0.047) 0.58 1.68 (1.24) 0.18 −5.8 (3.0) 0.056

CETP

 TaqIB (B1B1) B1B2 −0.025 (0.033) 0.45 2.13 (0.86) 0.014 3.0 (2.2) 0.16

B2B2 −0.095 (0.047) 0.04 6.62 (1.22) 6.7 × 10−8 0.1 (3.0) 0.98

 −2505C/A (CC) CA −0.055 (0.032) 0.90 2.92 (0.84) 5.5 × 10−4 0.2 (2.1) 0.91

AA −0.111 (0.052) 0.03 6.72 (1.34) 6.6 × 10−7 4.7 (3.3) 0.16

 −629C/A (CC) CA −0.026 (0.038) 0.49 0.92 (0.98) 0.35 1.5 (2.4) 0.55

AA −0.088 (0.043) 0.04 5.18 (1.12) 4.7 × 10−6 0.7 (2.8) 0.81

 A373P (AA) AP 0.115 (0.051) 0.03 −3.03 (1.34) 0.024 4.2 (3.3) 0.21

PP 0.530 (0.338) 0.12 −18.78 (8.87) 0.035 −1.0 (21.7) 0.96

 R451Q (RR) RQ 0.114 (0.058) 0.049 −3.39 (1.52) 0.026 5.7 (3.7) 0.13

QQ 0.528 (0.338) 0.12 −18.75 (8.87) 0.035 −0.9 (21.7) 0.97
a

Adjusted for age, sex, race/ethnicity, BMI, waist circumference, diabetes, serum insulin level, smoking, and use of lipid-lowering medications.

b

To convert triglyceride concentrations to mmol/L, multiply by 0.0113; to convert HDL-C and LDL-C concentrations to mmol/L, multiply by 0.0259. Triglyceride values are log-transformed.

c

P values are based on t-test comparing mean of comparison genotype to the indicated reference genotype for each polymorphism using a codominant model.