Table 2.
Differences in HDL subclass particle concentrations between ABCA1 and CETP polymorphisms compared with reference genotype, in a subsample of the MESA population.a
| Polymorphism (reference genotype) | Comparison genotype | Large HDL, μmol/L
|
Medium HDL, μmol/L
|
Small HDL, μmol/L
|
HDL size, nm
|
||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SE) | P b | Mean (SE) | P | Mean (SE) | P | Mean (SE) | P | ||
| ABCA1 | |||||||||
|
| |||||||||
| 1051G/A (GG) | GA | −0.25 (0.24) | 0.30 | −0.51 (0.30) | 0.086 | 0.63 (0.32) | 0.045 | −0.02 (0.02) | 0.48 |
|
| |||||||||
| AA | 0.33 (0.33) | 0.32 | −1.11 (0.41) | 0.007 | 0.99 (0.44) | 0.024 | 0.02 (0.03) | 0.51 | |
|
| |||||||||
| CETP | |||||||||
|
| |||||||||
| TaqIB (B1B1) | B1B2 | 0.47 (0.23) | 0.040 | −0.01 (0.29) | 0.98 | −0.65 (0.31) | 0.035 | 0.08 (0.02) | 0.001 |
|
| |||||||||
| B2B2 | 1.77 (0.32) | 5.7 × 10−8 | 0.32 (0.41) | 0.43 | −1.61 (0.43) | 2.1 × 10−4 | 0.20 (0.03) | 5.7 × 10−9 | |
|
| |||||||||
| −2505C/A (CC) | CA | 0.88 (0.22) | 9.4 × 10−5 | −0.20 (0.28) | 0.49 | −0.86 (0.30) | 0.004 | 0.12 (0.02) | 8.3 × 10−8 |
|
| |||||||||
| AA | 1.95 (0.36) | 5.3 × 10−8 | −0.83 (0.45) | 0.065 | −0.79 (0.48) | 0.10 | 0.20 (0.04) | 7.5 × 10−8 | |
|
| |||||||||
| −629C/A (CC) | CA | 0.15 (0.26) | 0.57 | 0.01 (0.33) | 0.99 | −0.48 (0.35) | 0.17 | 0.04 (0.03) | 0.14 |
|
| |||||||||
| AA | 1.28 (0.30) | 2.0 × 10−5 | 0.04 (0.38) | 0.91 | −1.07 (0.40) | 0.008 | 0.16 (0.03) | 2.8 × 10−7 | |
|
| |||||||||
| A373P (AA) | AP | −0.95 (0.36) | 0.008 | 0.39 (0.45) | 0.38 | 0.74 (0.48) | 0.12 | −0.10 (0.04) | 6.2 × 10−3 |
|
| |||||||||
| PP | −5.29 (2.36) | 0.025 | 1.79 (2.96) | 0.54 | −1.83 (3.15) | 0.56 | −0.37 (0.24) | 0.13 | |
|
| |||||||||
| R451Q (RR) | RQ | −0.81 (0.40) | 0.044 | 0.30 (0.51) | 0.55 | 0.76 (0.54) | 0.16 | −0.08 (0.04) | 0.072 |
|
| |||||||||
| −5.25 (2.36) | 0.027 | 1.78 (2.96) | 0.55 | −1.84 (3.15) | 0.56 | −0.37 (0.24) | 0.14 | ||
a
Values are adjusted for age, sex, race/ethnicity, BMI, waist circumference, diabetes, serum insulin level, smoking, and use of lipid-lowering medications.
b
P values are based on t-test comparing mean of comparison genotype to the indicated reference genotype for each polymorphism using a codominant model.