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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: Clin Chem. 2009 Jan 8;55(3):481–488. doi: 10.1373/clinchem.2008.107995

Table 3.

Differences in LDL subclass particle concentrations between ABCA1 and CETP polymorphisms compared with reference genotype, in a subsample of the MESA population.a

Polymorphism (reference genotype) Comparison genotype Large LDL, nmol/L
Small LDL, nmol/L
LDL size, nm
Mean (SE) P b Mean (SE) P Mean (SE) P
ABCA1
 1051G/A (GG) GA −19.5 (12.9) 0.13 28.0 (29.5) 0.34 −0.1 (0.1) 0.12
AA −23.6 (17.9) 0.19 −0.8 (40.8) 0.99 0.0 (0.1) 0.97
CETP
 TaqIB (B1B1) B1B2 42.5 (12.6) 0.001 −80.8 (28.6) 0.005 0.2 (0.1) 0.001
B2B2 81.0 (17.7) 5.2 × 10−6 −173.0 (40.3) 1.9 × 10−5 0.3 (0.1) 2.3 × 10−7
 −2505C/A (CC) CA 55.1 (12.2) 6.7 × 10−6 −114.0 (27.8) 4.4 × 10−5 0.2 (0.1) 2.8 × 10−6
AA 87.4 (19.4) 7.3 × 10−6 −137.4 (44.2) 0.002 0.3 (0.1) 1.7 × 10−5
 −629C/A (CC) CA 25.7 (14.3) 0.072 −47.2 (32.5) 0.15 0.1 (0.1) 0.058
AA 61.0 (16.4) 2.1 × 10−4 −128.6 (37.2) 0.001 0.3 (0.1) 7.5 × 10−6
 A373P (AA) AP −34.1 (19.4) 0.08 135.6 (44.0) 0.002 −0.2 (0.1) 0.01
PP −300.5 (128.5) 0.02 786.7 (291.1) 0.007 −1.2 (0.5) 0.01
 R451Q (RR) RQ −16.4 (22.0) 0.46 118.3 (49.9) 0.02 −0.2 (0.1) 0.06
QQ −297.7 (128.7) 0.02 781.5 (291.6) 0.007 −1.2 (0.5) 0.01
a

Values are adjusted for age, sex, race/ethnicity, BMI, waist circumference, diabetes, serum insulin level, smoking, and use of lipid-lowering medications.

b

P values are based on t-test comparing mean of comparison genotype to the indicated reference genotype for each polymorphism using a codominant model.