Skip to main content
. Author manuscript; available in PMC: 2018 Jun 14.
Published in final edited form as: Cell. 2017 Dec 7;171(7):1573–1588.e28. doi: 10.1016/j.cell.2017.11.008

Figure 2. YY1 Generally Occupies Enhancers and Promoters in Mammalian Cells.

Figure 2

(A and B) Heatmaps displaying the YY1 occupancy at enhancers (A) and active promoters (B) in six human cell types. (C–E) Summaries of the major classes of high-confidence interactions identified with YY1 HiChIP in colorectal cancer cells (C), T cell acute lymphoblastic leukemia cells (D), and chronic myeloid leukemia cells (E).

(F–K) Examples of YY1-YY1 enhancer-promoter interactions in three human cell types: colorectal cancer (F and I), T cell acute lymphoblastic leukemia (G and J), and chronic myeloid leukemia (H and K). Displayed examples show YY1-YY1 enhancer-promoter interactions involving typical enhancers (F–H) and involving super-enhancers (I–K).

See also Figure S2. See STAR Methods for detailed description of genomics analyses. Datasets used in this figure are listed in Table S4.

HHS Vulnerability Disclosure