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Putative direct targets of PITX1 are strongly associated with limb patterning, chondrogenesis and myogenesis in mouse hindlimbs. A–B) The top 10 enriched clusters associated with A) up- and B) down-regulated candidate targets of PITX1 in mouse hindlimbs. C) Mouse and mouse/Anolis conserved PITX1 binding sites are both significantly enriched near genes that are misexpressed in Pitx1−/− mouse hindlimbs.
