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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):467–472. doi: 10.1038/nature25432

Figure 1. Human metastases enrich for CIN.

Figure 1

a, wGII of matched primary tumors (P) and brain metastases (M), n = 79 patients. b–c, Karyotype probability density (b) and chromosomal aberrations (c) in 983 primary tumor and 186 metastatic breast cancer clones. d, Images of a head and neck squamous cell carcinoma cells undergoing anaphase. Arrows point to chromosome missegregation, scale bar 5-μm. Right, Chromosome missegregation in tumors from patients with (N+, n = 22 patients) or without (N-, n = 18 patients) clinically detectable lymph node metastases. Boxes represent median ± interquartile range, confidence intervals denote 10th–90th percentile (a, c–d), significance tested using two-sided Wilcoxon matched-pairs signed rank test (a) and two-sided Mann Whitney test (b–d).