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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):467–472. doi: 10.1038/nature25432

Figure 3. Opposing roles for CIN in primary tumors and metastases.

Figure 3

a, Experimental schema. b–d, Chromosome missegregation in injected cells (blue), cells derived from primary tumors (green), metastases (met) arising spontaneously (orange) or after intracardiac injection (red). ST, soft tissue. Bars represent mean ± SD, n = 150 cells, 3 independent experiments, *p < 0.05, #p < 0.05, **p < 0.05 denote samples with higher or lower chromosome missegregation than the injected lines, and spontaneous metastases with higher missegregation than matched primary tumors, respectively. Significance tested using two-sided t-test (b–d).