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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):467–472. doi: 10.1038/nature25432

Figure 4. CIN enriches for mesenchymal cell traits.

Figure 4

a, Heatmap showing expression of EMT genes in 6,821 MCAK, Kif2b, and dnMCAK expressing MDA-MB-231 cells. b, Above, t-stochastic neighbor embedding (tSNE) projection of all cells in a. Below, Heatmap of normalized enrichment score (NES) for pathways with an FDRq < 0.05 based on GSEA using one-sided Weighted Smirnov-Kolmogorov test on subpopulations identified using Phenograph. Boxes outline populations with mutually exclusive transcriptional profiles.