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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Alcohol Clin Exp Res. 2017 Dec 19;42(2):413–423. doi: 10.1111/acer.13551

Table 2.

Linear mixed-effects models for alcohol dependence symptoms (natural log transformed) across two GW and DHS polygenic score thresholds (N = 1,098)

Threshold GW scores
Beta 95% CI P Pseudo-R2 SNP Count Per-SNP R2
P<.01 0.0006 0.0003 – 0.0010 0.0003 0.011 2,221 4.96E-06
P<.05 0.0003 0.0001 – 0.0006 0.0006 0.010 10,694 9.57E-07
Threshold DHS scores
Beta 95% CI P Pseudo-R2 SNP Count Per-SNP R2
P<.01 0.0008 0.0001 – 0.0014 0.0094 0.005 789 6.76E-06
P<.05 0.0004 0.00001 – 0.0008 0.0220 0.004 3,947 1.03E-06

Notes. All models include sex as a covariate. Pseudo-R2 calculated using the method outlined by Nakagawa et al. (2013). Abbreviations: GW, genome-wide; DHS, DNase I hypersensitive sites.