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a, Close up view of the M4–M5 connector with side chains depicted on it (sticks). ICMT is predominately gray, with the M4–M5 connector coloured yellow. Amino acids that interact with Phe123 (Ile64, Leu71, and Phe107) are coloured grey. b, The N-terminal end of the M5 helix is capped by Ser128. The side chain of Ser128 is shown, in stick representation, with the hydrogen bond to the backbone nitrogen atom of Tyr131 indicated by a dotted line.
