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. 2018 Jan 25;8:1603. doi: 10.1038/s41598-017-16703-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Human synaptic plasticity gene expression in ND-EFV exposed SK-N-MC cells. 84 genes analyzed that is related to the synaptic plasticity of the neurons through PCR array analysis. The only genes that significantly up (in red) /down (in blue) regulated (± ≥3 fold) are shown on the table. (a) 3D-profile of fold change of synaptic plasticity genes in ND exposed SK-N-MC cells. (b) Representative figures for scatter plot analysis of the changes in synaptic plasticity gene expression in ND-EFV exposed SK-N-MC cells: Spots associated with individual human synaptic plasticity gene were collected and converted into log₁₀ scale. The central line indicates unchanged gene expression. The synaptic plasticity genes with expression levels higher or lower in treated neuronal cells than control cells are expected to produce dots that deviate from the centerline. The dots are allocated to positions that are above or below than the +3 fold or 3-fold line when the differences are greater than three folds. (c) Human synaptic plasticity genes expression in ND-EFV exposed SK-N-MC cells (fold change): Out of 84 genes analyzed, only genes significantly (± ≥ 3 fold) dysregulated were shown in this table (d) Gene-Gene interaction network for human synaptic plasticity genes dysregulated in ND-EFV exposed SK-N-MC cells.